MAO A/HSP90-IN-1_product_DataBase

Bioactivity	MAO A/HSP90-IN-1 (4-b) is a MAO A/HSP90 dual inhibitor with IC50 value of 1.77 μM and 0.019 μM in Glioblastoma (GBM) GL26 cells and HSP90α, respectively. MAO A/HSP90-IN-1 (4-b) can inhibit MAO A activity, HSP90 binding and the expression of HER2 and phospho-Akt to inhibit the growth of GBM, they also reduce PD-L1 expression, which inhibits T cell activation. MAO A/HSP90-IN-1 (4-b) have potential to inhibit tumor immune escape. MAO A/HSP90-IN-1 (4-b) can be used for brain tumor-related diseases research[1].
Invitro	MAO A/HSP90-IN-1 (4-b) (0.1 μM-3 μM, 24小时) 通过抑制 MAO A 和 HSP90，从而减少 GBM 细胞的增殖[1]。MAO A/HSP90-IN-1 (0.1 μM-3 μM, 24小时) 在 GL26 中的 IC50 为0.73 μM，在GL26中的 IC50 为1.68 μM，在 U251R 中的 IC50 为0.84 μM[1]。MAO A/HSP90-IN-1 (0μM, 0.35μM, 0.7μM, 1.4μM, 24小时) 在小鼠胶质瘤 GL26 细胞中抑制IFN-γ 诱导的PD-L1表达[1]。 0 --> MAO A/HSP90-IN-1 相关抗体: Cell Viability Assay[1] Cell Line:
In Vivo	MAO A/HSP90-IN-1 (4-b) (25 mg/kg，腹腔注射，每天) 抑制 GBM 小鼠模型肿瘤生长[1]。 Animal Model:
Name	MAO A/HSP90-IN-1
CAS	2927489-95-8
Formula	C24H29ClN2O4
Molar Mass	444.95
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Tseng HJ, et al. Design, synthesis, and biological activity of dual monoamine oxidase A and heat shock protein 90 inhibitors, N-Methylpropargylamine-conjugated 4-isopropylresorcinol for glioblastoma. Eur J Med Chem. 2023 Aug 5;256:115459.

PeptideDB

MAO A/HSP90-IN-1

CAS: 2927489-95-8 F: C24H29ClN2O4 W: 444.95