MAO-A/B-IN-3_product_DataBase

Bioactivity	MAO-A/B-IN-3 (Compound 12) stands out as a key dual MAO-AChE inhibitor, displaying excellent multi-target efficacy against MAO-A, MAO-B, and AChE with IC50 values of 67 nM, 29 nM, and 1370 nM respectively. MAO-A/B-IN-3 is adept at altering the A site (hydrophobic ring) and C site (semicarbazone chain) within ketone amine-based MTDLs to bolster the inhibitory potential against MAO-A/B while notably diminishing activity against AChE. MAO-A/B-IN-3 is poised for research applications in the field of neurodegenerative diseases[1].
Invitro	MAO-A/B-IN-3 (Compound 12) 在体外Caco2细胞穿透性实验中表现出中等的渗透性 (16.49 nm/s) [1]。MAO-A/B-IN-3 对MDCK细胞显示出中等的穿透性 (103.16 nm/s) [1]。MAO-A/B-IN-3 显示90.97%的血浆蛋白结合率，结合率大于90% 代表强结合率，表明它具有较长的半衰期和缓慢的排泄特性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> MAO-A/B-IN-3 相关抗体:
In Vivo	MAO-A/B-IN-3 (Compound 12) (20 mg/kg；腹腔注射；60分钟) 增加了动物的不动期，因此被认为是中枢神经系统抑制剂[1]。MAO-A/B-IN-3 (30 mg/kg；腹腔注射；30分钟) 具有显著的抗焦虑活性，其中一些化合物显示出比参考药物地西泮更优越的活性[1]。MAO-A/B-IN-3 (30 mg/kg；腹腔注射；0.5小时和4小时) 在雄性白种小鼠中至少到4小时内不具有神经毒性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	315210-31-2
Formula	C17H16N4O2
Molar Mass	308.33
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Kumar S, et al. Benzimidazole-derived carbohydrazones as dual monoamine oxidases and acetylcholinesterase inhibitors: design, synthesis, and evaluation[J]. Journal of Biomolecular Structure and Dynamics, 2023: 1-20.

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MAO-A/B-IN-3

CAS: 315210-31-2 F: C17H16N4O2 W: 308.33