MANS peptide_product_DataBase

Bioactivity	MANS peptide is an inhibitor for myristoylated alanine-rich C kinase substrate (MARCKS), which competes with MARCKS in cells for membrane binding, and thus inhibits the stimulation of mucin secretion and tumor metastasis[1].
Invitro	MANS peptide (0-100 μM，12-24 h) 抑制肺癌细胞 CL1-0/F3、CL1-5、PC9 和 A549 的迁移和侵袭，而不对正常细胞造成毒性[1]。MANS peptide (0-100 μM，16 h) 抑制 MARCKS，PI3K 和 AKT 磷酸化，导致 Slug 信号下游和 E-钙粘蛋白表达水平的变化，防止细胞间粘附丧失，改变癌细胞的上皮-间质间转化 (EMT) 特征，从而减少肿瘤转移[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> MANS peptide 相关抗体: Cell Viability Assay[1] Cell Line:
In Vivo	MANS peptide (50 nmol/injection，腹腔注射，每 3 天一次，共 6 次) 可抑制 PC9 异种移植 NOD/SCID 小鼠模型中的肿瘤转移，但不影响肿瘤发生[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	479482-23-0
Sequence	{Myristic acid-Gly}-Ala-Gln-Phe-Ser-Lys-Thr-Ala-Ala-Lys-Gly-Glu-Ala-Ala-Ala-Glu-Arg-Pro-Gly-Glu-Ala-Ala-Val-Ala
Shortening	{Myristic acid-Gly}-AQFSKTAAKGEAAAERPGEAAVA
Formula	C111H184N30O35
Molar Mass	2498.83
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Chen CH, et al., A peptide that inhibits function of Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) reduces lung cancer metastasis. Oncogene. 2014 Jul 10;33(28):3696-706.

PeptideDB

MANS peptide

CAS: 479482-23-0 F: C111H184N30O35 W: 2498.83