| Bioactivity | MANS peptide TFA is the TFA salt form of MANS peptide (HY-P10218). MANS peptide TFA is an inhibitor for myristoylated alanine-rich C kinase substrate (MARCKS), which competes with MARCKS in cells for membrane binding, and thus inhibits the stimulation of mucin secretion and tumor metastasis[1]. | ||||||
| Invitro | MANS peptide TFA (0-100 μM, 12-24 h) 抑制肺癌细胞 CL1-0/F3、CL1-5、PC9 和 A549 的迁移和侵袭，而不对正常细胞造成毒性[1]。MANS peptide TFA (0-100 μM, 16 h) 抑制 MARCKS，PI3K 和 AKT 磷酸化，导致 Slug 信号下游和 E-钙粘蛋白表达水平的变化，防止细胞间粘附丧失，改变癌细胞的上皮-间质间转化 (EMT) 特征，从而减少肿瘤转移[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> MANS peptide TFA 相关抗体: Cell Migration Assay [1] Cell Line: | ||||||
| In Vivo | MANS peptide TFA (50 nmol/injection，腹腔注射，每 3 天一次，共 6 次) 可抑制 PC9 异种移植 NOD/SCID 小鼠模型中的肿瘤转移，但不影响肿瘤发生[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: | ||||||
| Sequence | {Myristic acid-Gly}-Ala-Gln-Phe-Ser-Lys-Thr-Ala-Ala-Lys-Gly-Glu-Ala-Ala-Ala-Glu-Arg-Pro-Gly-Glu-Ala-Ala-Val-Ala | ||||||
| Shortening | {Myristic acid-Gly}-AQFSKTAAKGEAAAERPGEAAVA | ||||||
| Formula | C111H184N30O35.xC2HF3O2 | ||||||
| Molar Mass | 2498.83 (free acid) | ||||||
| Appearance | 固体 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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| Reference | [1]. Chen CH, et al., A peptide that inhibits function of Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) reduces lung cancer metastasis. Oncogene. 2014 Jul 10;33(28):3696-706. |
MANS peptide TFA
CAS: F: C111H184N30O35.xC2HF3O2 W: 2498.83 (free acid)
MANS peptide TFA is the TFA salt form of MANS peptide (HY-P10218). MANS peptide TFA is an inhibitor for myristoylated al
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