| Bioactivity | MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein). MAK683-CH2CH2COOH and a VHL ligand for the E3 ubiquitin ligase have been used to design PROTAC EED degrader-1 (HY-130614) and PROTAC EED degrader-2 (HY-130615)[1]. |
| Invitro | MAK683-CH2CH2COOH 抑制 Karpas422 细胞，GI50 为 14 nM，处理 14 天[1]。 |
| Name | MAK683-CH2CH2COOH hydrochloride |
| Formula | C23H22ClFN6O3 |
| Molar Mass | 484.91 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen) |
| Reference | [1]. Hsu JH, et al. EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex. Cell Chem Biol. 2019 Nov 26. pii: S2451-9456(19)30362-9. |
MAK683-CH2CH2COOH hydrochloride
CAS: F: C23H22ClFN6O3 W: 484.91
MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein). MAK683-CH2CH2COOH and a VHL ligand for the E3 u
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