| Bioactivity | MAIT-203, a cyclopentyalanin-derived peptidomimetic, potently inhibits the interaction of adenomatous polyposis coli (APC) and Asef (RhoGEF4), but not APC-Sam68 or APC-striatin interactions. MAIT-203 binds APC-ARM with a Ki of 0.015 μM and a Kd of 0.036 μM. MAIT-203 significantly represses the migration and invasion of colorectal cancer cells. |
| Invitro | MAIT-203 (10 μM and 25 μM; for 24 h) reduces Asef-APC interaction in a dose-dependent manner in HEK293T cells[1]. MAIT-203 (10 μM) significantly attenuates SW480 and HCT116 cell migration[1]. Incubation of SW480 cells with MAIT-203 (25, 50 μM;for 24 h) results in a dose-dependent decrease in the amount of the active form of CDC42, but not Rac1[1]. |
| Name | MAIT-203 |
| Shortening | Z-AGEA-{S-3cyclopentylalamine}-YEGGGGGRKKRRQRRR-NH2 |
| Formula | C106H177N43O29 |
| Molar Mass | 2517.85 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |