| Bioactivity | MAGL-IN-9 (compound 16) is a selective and reversible MAGL inhibitor with IC50 2.7 nM[1]. |
| Target | IC50: 2.7 nM (MAGL) |
| Invitro | MAGL-IN-9 (10 μM, 25 min) 在小鼠脑膜制剂中选择性抑制 MAGL，而不影响其他丝氨酸水解酶如FAAH, ABHD6, ABHD12[1]。MAGL-IN-9 (5 μM, 60 min) 在预孵育和稀释试验中均表现出具有可逆的抑制机制[1]。MAGL-IN-9 (30 min) 在 U973 细胞中能够抑制 MAGL, IC50 值为 193 nM[1]。 0 --> MAGL-IN-9 相关抗体: |
| Name | MAGL-IN-9 |
| Formula | C25H22F4N2O2S |
| Molar Mass | 490.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Di Stefano M, et al. Design, synthesis, ADME and biological evaluation of benzylpiperidine and benzylpiperazine derivatives as novel reversible monoacylglycerol lipase (MAGL) inhibitors[J]. European Journal of Medicinal Chemistry, 2023: 115916. |