| Bioactivity | MAC-5576 is a SARS-CoV-2 3CL protease inhibitor, with an IC50 of 81 nM. MAC-5576 also inhibits 3CLpro (IC50 = 0.5 μM), HAV 3Cpro (IC50 = 0.5 μM), and thrombin (IC50 = 13 μM)[1][2]. |
| CAS | 219929-01-8 |
| Formula | C10H6ClNO2S |
| Molar Mass | 239.68 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jan E Blanchard, et al. High-throughput screening identifies inhibitors of the SARS coronavirus main proteinase. Chem Biol. 2004 Oct;11(10):1445-53. [2]. Sho Iketani, et al. Lead compounds for the development of SARS-CoV-2 3CL protease inhibitors. Nat Commun. 2021 Apr 1;12(1):2016. |