| Bioactivity | M826 is a potent, selective and reversible non-peptide caspase-3 inhibitor with an IC50 value of 0.005 μM for enzymatic activity against caspase-3. M826 displays potent anti-apoptotic activity in animal models in vitro and in vivo. M826 can be used for nervous system diseases research[1]. |
| Invitro | M826 (不同浓度, 20 小时) 抑制 NT2 细胞凋亡[1] 0 --> M826 相关抗体: |
| In Vivo | M826 (30 nmol, 侧脑室注射) 阻止新生缺氧缺血 (H-I) 大鼠模型中 Caspase-3 的激活及其底物的裂解[1]。 |
| Name | M826 |
| Formula | C28H45N7O6 |
| Molar Mass | 575.70 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Han BH, et al. Selective, reversible caspase-3 inhibitor is neuroprotective and reveals distinct pathways of cell death after neonatal hypoxic-ischemic brain injury. J Biol Chem. 2002 Aug 16;277(33):30128-36. |