M62812 free base_product_DataBase

Bioactivity	M62812 (free base) is a toll-like receptor 4 (TLR4) signal transduction inhibitor. M62812 can suppress endothelial cell and leukocyte activation and prevents lethal septic shock in mice. M62812 can be used for the research of sepsis[1].
Invitro	M62812 (0-10 μg/ml) 抑制人血管内皮细胞和外周单核细胞中 LPS 诱导的炎性细胞因子、粘附分子和促凝活性的上调[1]。
In Vivo	M62812 (i.v.; 10-20 mg/kg; single) 在小鼠 d-半乳糖胺致敏内毒素休克模型中保护小鼠免受致死并降低炎症和凝血参数[1]。M62812 (20 mg/kg/day) 在小鼠盲肠结扎和穿刺模型中防止小鼠死亡[1]。 Animal Model:
Name	M62812 free base
CAS	613262-61-6
Formula	C13H11N3OS
Molar Mass	257.31
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Nakamura M, et al. Toll-like receptor 4 signal transduction inhibitor, M62812, suppresses endothelial cell and leukocyte activation and prevents lethal septic shock in mice. Eur J Pharmacol. 2007;569(3):237-243.

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