| Bioactivity | M5N36 is a potent and selective Cdc25C inhibitor with IC50 values of 0.15, 0.19, 0.06 µM for Cdc25A, Cdc25B, Cdc25C, respectively. M5N36 shows anti-proliferative activity and increases the expression of p-CDK1 and p-CDK2[1]. |
| Target | IC50: 0.15 µM (Cdc25A); 0.19 µM (Cdc25B); 0.06 µM (Cdc25C) |
| Invitro | M5N36 (5, 10 µM; 24 h) 增加 MDA-MB-231 细胞中 p-CDK1 和 p-CDK2 的表达[1]。 Cell Proliferation Assay[1] Cell Line: |
| Name | M5N36 |
| CAS | 2832887-40-6 |
| Formula | C20H16ClN5O3 |
| Molar Mass | 409.83 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Tao Y, et al. Discovery of potent and selective Cdc25 phosphatase inhibitors via rapid assembly and in situ screening of Quinonoid-focused libraries. Bioorg Chem. 2021 Oct;115:105254. |