| Bioactivity | M4K2308 is a selective ether-linked inhibitor of ALK2 with an IC50 of 2 nM. M4K2308 exhibits exceptional selectivity for ALK2 over ALK5 (IC50 of 224 nM). M4K2308 has the potential for the study of diffuse intrinsic pontine glioma (DIPG) research[1]. |
| CAS | 3034840-18-8 |
| Formula | C26H29N3O4 |
| Molar Mass | 447.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Héctor González-Álvarez, et al. Discovery of Conformationally Constrained ALK2 Inhibitors. J Med Chem. 2024 Mar 28;67(6):4707-4725. |