| Bioactivity | M4K2281 is a selecitve inhibitor for activin receptor-like kinase-2 (ALK2) with an IC50 of 2 nM. M4K2281 exhibits a moderate blood brain permeability with a brain to plasma ratio of 3.7 at 4h[1]. |
| In Vivo | M4K2281 (25 mg/kg，口服，单剂量) 在 NOD-SCID 小鼠模型中 1 小时和 24 小时的暴露血浆浓度 Cmax 分别为 5053 和 0 nM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| Formula | C27H31N3O4 |
| Molar Mass | 461.55 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. González-Álvarez H, et al., Discovery of Conformationally Constrained ALK2 Inhibitors. J Med Chem. 2024 Mar 28;67(6):4707-4725. |