| Bioactivity | M47 is a small molecule that selectively destabilizes Cryptochrome 1 (CRY1) and increases degradation of the CRY1 in the nucleus. M47 enhances apoptosis in Ras-transformed P53-deficient mouse skin fibroblast lines and enhances life span in p53 knockout mice. M47 can be used in research of cancer[1]. |
| Invitro | M47 (0-10 μM; 0-120 h; U2OS Bmal1-dLuc 细胞) 以剂量依赖性方式降低 CRY1 的半衰期并引起昼夜节律变化[1]。M47 (10 μM; 24-44 h) 降低 U2OS 细胞中 CRY1 的水平[1]。 Western Blot Analysis[1] Cell Line: |
| Name | M47 |
| CAS | 890808-56-7 |
| Formula | C28H22ClNO4 |
| Molar Mass | 471.93 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |