| Bioactivity | M2I-1 is a Mad2 inhibitor targeting the binding of Mad2 to Cdc20, an essential protein-protein interaction (PPI) within the spindle assembly checkpoint (SAC)[1]. | ||||||||||||
| Target | Mad2 | ||||||||||||
| Invitro | M2I-1 may not be sufficiently potent to fully inhibit SAC function in cells[1].M2I-1 weakens the SAC response, indicating that the compound might be active in cells.[1]. | ||||||||||||
| Name | M2I-1 | ||||||||||||
| CAS | 312271-03-7 | ||||||||||||
| Formula | C19H24N4O4S | ||||||||||||
| Molar Mass | 404.48 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Johanna Kastl et al. Mad2 Inhibitor-1 (M2I-1): A Small Molecule Protein-Protein Interaction Inhibitor Targeting the Mitotic Spindle Assembly Checkpoint. ACS Chem. Biol., 2015, 10 (7), pp 1661-1666. |