| Bioactivity | M109S is a novel small molecule protecting cells from mitochondria-dependent apoptosis both in vitro and in vivo. M109S has the potential to become a research tool for studying cell death mechanisms and to develop therapeutics targeting mitochondria-dependent cell death pathway. M109S has orally bioactivity with excellent brain permeability[1]. |
| Invitro | M109S (0.1-10000 nM, 24-48 h) 抑制 Bax 和 Bak 诱导的细胞凋亡 (apoptosis)[1]。M109S (0-10 μM, 4 h) 抑制 Staurosporine (HY-15141 STS) 诱导的 MEF 细胞凋亡 (apoptosis)。M109S (0-10μM, 24 h) 抑制 Etoposide (HY-13629) 诱导的 Neuro2a 细胞凋亡 (apoptosis)[1]。M109S (500 nM, 24 h) 抑制 Obatoclax (HY-10969A) 诱导的 ARPE19 细胞凋亡 (apoptosis)[1]。M109S (500 nM, 48 h) 抑制 Bax 的构象改变 (N 端暴露) 和线粒体易位[1]。M109S (1.0 μM, 4h) 降低线粒体耗氧量和活性氧，而 M109S (0.1-1 nM, 4 h) 增加糖酵解[1]。 0 --> M190S 相关抗体: Apoptosis Analysis[1] Cell Line: |
| In Vivo | M109S (10 mg/kg, 灌胃, 48 h 内 3 次) 可保护视网膜免受强光诱导的光感受器死亡[1]。M109S (1mg /kg, 腹腔注射, 5 mg /kg, 静脉注射, 或10 mg /kg, 口服灌胃, 1次) 是一种穿透血脑/视网膜屏障的口服生物活性细胞死亡 (cell death) 抑制剂[1]。 Animal Model: |
| Name | M190S |
| CAS | 2578300-07-7 |
| Formula | C21H21N5O2 |
| Molar Mass | 375.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mieko Matsuyama, et al. Development of novel cytoprotective small compounds inhibiting mitochondria-dependent cell death. Science 26, 107916, October 20, 2023 |