| Bioactivity | M084 is a benzimidazole derivative. M084 inhibits the mitochondrial respiration, activate mitochondrial unfolded protein response and AMPK, recruites SIR-2.1 and SKN-1, and finally through the transcription factor DAF-16, delays the aging process of C. elegans[1]. | ||||||||||||
| Name | M084 | ||||||||||||
| CAS | 51314-51-3 | ||||||||||||
| Formula | C11H15N3 | ||||||||||||
| Molar Mass | 189.26 | ||||||||||||
| Appearance | 固体 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Ai-Jun Ding, et al. Benzimidazole derivative M084 extends the lifespan of Caenorhabditis elegans in a DAF-16/FOXO-dependent way. Mol Cell Biochem. 2017 Feb;426(1-2):101-109. |