| Bioactivity | M-COPA (AMF-26) is an inhibitor of ADP ribosylation factor 1 (Arf1)-mediated vesicle transport. M-COPA disrupts the structure of the Golgi apparatus, inhibits the processing and transport of receptor tyrosine kinases (RTKs) to the cell surface and extracellular space, thereby exerting antitumor activity against RTK-addicted cancers[1]. |
| CAS | 861718-91-4 |
| Formula | C25H34N2O2 |
| Molar Mass | 394.55 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ohashi Y, et al. M-COPA, a Golgi Disruptor, Inhibits Cell Surface Expression of MET Protein and Exhibits Antitumor Activity against MET-Addicted Gastric Cancers. Cancer Res. 2016 Jul 1;76(13):3895-903. |