Lys-SMCC-DM1_product_DataBase

CAS: 1281816-04-3 F: C53H75ClN6O15S W: 1103.71

Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) is a drug-linker conjugates for ADC that can inhibit tubulin polymerization. Lys-SMCC-DM1

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity	Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) is a drug-linker conjugates for ADC that can inhibit tubulin polymerization. Lys-SMCC-DM1 is the active metabolite of T-DM1. T-DM1 is a HER2-targeting ADC with a tubulin polymerization inhibitor DM1. Lys-SMCC-DM1 can be used in the research of breast cancer[1][2].
Invitro	Lys-SMCC-DM1 具有低渗透性[1]。Lys-SMCC-DM1 在 KPL-4 和 MDA-MB-468 细胞中表现出细胞毒性，IC50 分别为 24.8 nM 和 40.5 nM[2]。Lys-SMCC-DM1 (200 μM) 抑制 MDCKII/SLC46A3 dC 细胞中 SLC46A3 介导的雌酮 3-硫酸盐摄取[2]。
Name	Lys-SMCC-DM1
CAS	1281816-04-3
Formula	C53H75ClN6O15S
Molar Mass	1103.71
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

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