| Bioactivity | Lynestrenol is a pregnane X receptor (PXR) agonist with the EC50s of 41 and 0.23 µM for hPXR and zfPXR, respectively[1]. Lynestrenol, a synthetic progesteronelike agent possess immunostimulatory properties[2][3]. |
| Invitro | Lynestrenol markedly enhances the lymphocyte response to phytohemagglutinin, the mixed lymphocyte culture, the active T-rosette test, the autologous red cell rosettes, and the number of nonadherent cells in the leukocyte adherence inhibition test. Lynestrenol also increases monocyte phagocytosis. Lynestrenol delays the appearance of malignant tumors in hamsters[2]. |
| In Vivo | Lynestrenol has both a genotoxic and cytotoxic effects in mouse bone marrow cells. Lynestrenol is studied at three different doses (6.87, 13.75 and 27.50 mg/kg). Sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) increase significantly as compared to normal control when treated with Lynestrenol at 13.75 and 27.50 mg/kg. |
| Name | Lynestrenol |
| CAS | 52-76-6 |
| Formula | C20H28O |
| Molar Mass | 284.44 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Nicolas Creusot, et al. A Comparative Study of Human and Zebrafish Pregnane X Receptor Activities of Pesticides and Steroids Using In Vitro Reporter Gene Assays. Front Endocrinol (Lausanne). 2021 May 18;12:665521. [2]. J Wybran. Lynestrenol: a progesteronelike agent with immunostimulatory properties. Recent Results Cancer Res. 1980;75:180-4. [3]. Yasir Hasan Siddique, et al. In vivo induction of sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) by lynestrenol. Indian J Exp Biol. 2005 Mar;43(3):291-3. |