| Bioactivity | Lutikizumab (ABT-981) is an anti-IL-1α and IL-1β dual variable domain immunoglobulin. Lutikizumab binds and inhibits IL-1α and IL-1β. Lutikizumab can be used for the research of osteoarthritis[1]. |
| Invitro | ABT-981 可同时结合人 IL-α 和 IL-1β 分子[1]。ABT-981 对 IL-α 和 IL-1β 表现出高度特异性的结合作用相比于其他 IL-1 家族成员[1]。 |
| In Vivo | Lutikizumab (0.0001-1 mg/kg，腹腔注射，1 次) 对 IL-1α 和 IL-1β 诱导的 IL-6 产生有效抑制作用[1]。 Animal Model: |
| Name | Lutikizumab |
| CAS | 1791411-57-8 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lacy SE, et al. Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig(TM)) molecule that specifically and potently neutralizes both IL-1α and IL-1β. MAbs. 2015;7(3):605-19. |