Lupiwighteone_product_DataBase

Bioactivity	Lupiwighteone is an isoflavone present widely in wild-growing plants, with antioxidant, antimicrobial and anticancer effects. Lupiwighteone induces caspase-dependent and -independent apoptosis on human breast cancer cells via inhibiting PI3K/Akt/mTOR pathway[1][2].
Invitro	Lupiwighteone (2-100 μM; 72 hours) shows cytotoxicity towards various cell lines, especially on DU-145 cells and SGC-7901 cells with IC50s of 23.7 μM and 21 μM, respectively[2].Lupiwighteone (20-60 μM; 48 hours) induces (cell cycle arrest in DU-145 cells[2].Lupiwighteone (20-60 μM; 48 hours) induces cells apoptosis[2].Lupiwighteone (20-60 μM; 48 hours) decreases the cell cycle-related protein expressions in a dose-dependent manner in DU-145 cells[2].Lupiwighteone (20-60 μM; 48 hours) induces a dose-dependent increase in ROS production[2].Lupiwighteone up-regulates of cytochrome c and caspase-3, and subsequent cleavage of PARP-1 and down-regulates of the p-Akt/Akt ratio and VEGF expression, suggests the activation of mitochondria-based intrinsic apoptosis in DU-145 cells[2]. Cell Viability Assay[2] Cell Line:
Name	Lupiwighteone
CAS	104691-86-3
Formula	C20H18O5
Molar Mass	338.35
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

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