Bioactivity | Lumisterol 3 (>90%) (9β,10α-Cholesta-5,7-dien-3β-ol) is a normal human secosterooid metabolite from the class of vitamin D3 photoisomer derivatives. Lumisterol 3 (>90%) is used in the preparation of vitamin D[1]. |
Invitro | Lumisterol 3 (L3) (1-100 nM, 24 h) significantly reduces UVB-induced cellular oxidant formation in a dose-dependent manner and inhibits the proliferation of UVB-irradiated keratinocytes[2].Lumisterol 3 (L3) (100 nM, 24 h) promotes repair of cellular DNA damage induced by UVB irradiation and increases the nuclear/cytosolic Nrf2 ratio and nuclear p53 expression level in UVB-irradiated cells[2].Lumisterol 3 (L3) (100 nM, 3 h) significantly enhances the expression levels of Nrf2-regulated antioxidant proteins, including catalase and HO-1 in UVB-irradiated cells[2]. |
Name | Lumisterol 3 (>90%) |
CAS | 5226-01-7 |
Formula | C27H44O |
Molar Mass | 384.64 |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | -80°C, protect from light, stored under nitrogen *该产品在溶液状态不稳定,建议您现用现配,即刻使用。 |