Lucidone_product_DataBase

Bioactivity	Lucidone, an anti-inflammatory agent that can be isolated from the fruit of Lindera erythrocarpa Makino. Lucidone inhibits LPS-induced NO and PGE2 production in RAW 264.7 mouse macrophages. Lucidone also decreases TNF-α secretion, iNOS and COX-2 expression. Lucidone prevents NF-κB translocation and inhibits JNK and p38MAPK signals. Lucidone also has inhibitory activity against Dengue virus (DENV) (EC50=25 μM)[1][2].
Invitro	Lucidone (10 μg/mL, 25 μg/mL; 1 h 或 20 h) 降低 RAW 264.7 巨噬细胞受 LPS (1 μg/mL) 诱导而导致 TNF-α 分泌 (20 h) 以及 PGE2 产量 (1 h) 的增加[1]。Lucidone (10 μg/mL, 25 μg/mL; 8 h) 抑制 RAW 264.7 巨噬细胞受 LPS (1 μg/mL) 诱导而导致的 iNOS 和 COX-2 表达的增加[1]。Lucidone (10 μg/mL, 25 μg/mL; 1 h) 抑制 RAW 264.7 巨噬细胞受 LPS (1 μg/mL) 诱导而导致的 NF-κB p65/p50 水平的增加，以及 IKK 蛋白的磷酸化[1]。Lucidone (0-40 μM; 3 d) 降低感染 Huh-7 细胞中 DENV 的病毒滴度[2]。 Western Blot Analysis[1] Cell Line:
In Vivo	Lucidone (1 mg/kg; 颅内注射; 一周内 3 次) 显著提高 DENV 感染小鼠的存活率和体重[2]。 Animal Model:
Name	Lucidone
CAS	19956-53-7
Formula	C15H12O4
Molar Mass	256.25
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Senthil Kumar KJ, et aL. Lucidone inhibits iNOS and COX-2 expression in LPS-induced RAW 264.7 murine macrophage cells via NF-kappaB and MAPKs signaling pathways. Planta Med. 2009 Apr;75(5):494-500. [2]. Chen WC, et al. Lucidone suppresses dengue viral replication through the induction of heme oxygenase-1. Virulence. 2018 Jan 1;9(1):588-603.

PeptideDB

Lucidone

CAS: 19956-53-7 F: C15H12O4 W: 256.25