Lu AA47070_product_DataBase

Bioactivity	Lu AA47070 is a phosphonooxymethylene prodrug of a potent and selective Adenosine A2A receptor antagonist. Lu AA47070 reverses the motor and motivational effects produced by dopamine D2 receptor blockade[1][2].
In Vivo	Lu AA47070 (3.75、7.5、15、30 mg/kg；腹腔注射) 逆转由亚慢性给药 D2 拮抗剂匹莫齐特（1.0 mg/kg；腹腔注射）引起的下颌颤动、僵直和运动抑制[2]。 Animal Model:
Name	Lu AA47070
CAS	913842-25-8
Formula	C17H20F2N3O6PS
Molar Mass	463.39
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Discovery of Phosphoric Acid Mono-{2-[(E/Z)-4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-benzoylimino]-thiazol-3-ylmethyl} Ester (Lu AA47070): A Phosphonooxymethylene Prodrug of a Potent and Selective hA2A Receptor AntagonistJ. Med. Chem., Article ASAPDOI: 10.1021/jm1008659Publication Date (Web): January 6, 2011 [2]. Collins LE, et al. The novel adenosine A2A antagonist Lu AA47070 reverses the motor and motivational effects produced by dopamine D2 receptor blockade. Pharmacol Biochem Behav. 2012 Jan;100(3):498-505.

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