Longistyline A_product_DataBase

Bioactivity	Longistyline A (Longistylin A) is a natural stilbene, it can be isolated from leaves of Cajanus cajan. Longistyline A shows antimicrobial activity against MRSA with an MIC value of 1.56 μg/mL. Longistyline A shows neuroprotective effects, it can be used for the research of infection and nerve diseases[1][2].
Target	IC50: 8.61 μg/mL (murine RAW264.7 cells)
Invitro	Longistyline A (4-16 μM/L; 48 h) reduces the corticosterone-induced neurotoxicity in PC12 cells[1].Longistyline A can function as a membrane-targeting antibacterial agent by disturbing bacterial membrane potential and increasing the permeation[2].Longistyline A (0-100 μg/mL) shows significant antimicrobial activity against tested Gram-positive bacteria, such as B.cereus CMCC63302 with MIC values of 25 μg/mL, S.aureus CMCC26003 with MIC values of 1.56 μg/mL, and both two strains of MRSA (JCSC4744 and JCSC4469) with MIC values of 1.56 μg/mL[2].Longistyline A (24 h) shows cytotoxicity towards murine RAW264.7 cells with an IC50 value of 8.61 μg/mL[2]. Cell Cytotoxicity Assay[1] Cell Line:
In Vivo	Longistyline A (10 µg dissolved in 50 µL PBS buffer; apply to the wound; for 30 min) improves wound healing, decreases MRSA bacterial survivals in the lesions and reduces inflammatory reaction in MRSA infected mice[2]. Animal Model:
Name	Longistyline A
CAS	64095-60-9
Formula	C20H22O2
Molar Mass	294.39
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Jiang BP, et al. [Neuroprotective effect of longistyline A against corticosterone-induced neurotoxicity in PC12 cells]. Yao Xue Xue Bao. 2012 May;47(5):600-3. [2]. Wu J, et al. Longistylin A, a natural stilbene isolated from the leaves of Cajanus cajan, exhibits significant anti-MRSA activity. Int J Antimicrob Agents. 2020 Jan;55(1):105821.

PeptideDB

Longistyline A

CAS: 64095-60-9 F: C20H22O2 W: 294.39