| Bioactivity | Lonapalene (RS4317) is a topically effective 5-lipoxygenase (5-LO) inhibitor. | ||||||||||||
| Invitro | Lonapalene (RS4317) may be useful in the treatment of psoriasis, and that leukotriene B4 is a relevant mediator of the pathology of this disease[1]. | ||||||||||||
| Name | Lonapalene | ||||||||||||
| CAS | 91431-42-4 | ||||||||||||
| Formula | C16H15ClO6 | ||||||||||||
| Molar Mass | 338.74 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Black AK, et al. Pharmacologic and clinical effects of lonapalene (RS 43179), a 5-lipoxygenase inhibitor, in psoriasis. J Invest Dermatol. 1990 Jul;95(1):50-4. |