Bioactivity | Lithium citrate (Litarex) tetrahydrate is the major active ingredient of Garcinia cambogia. Lithium citrate tetrahydrate competitively inhibits ATP citrate lyase with weight loss benefits. Lithium citrate tetrahydrate effective inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation and anti-tumor effects[1][2][3][4]. |
Invitro | Lithium citrate tetrahydrate shows an HIF inhibitory effect compared with the control group in ARPE19 cells and 661W cells. Lithium citrate tetrahydrate can downregulate Hif1a and the downstream genes in ARPE19 cells and 661W cells. Lithium citrate tetrahydrate suppresses HIF-1α protein expression increased by CoCl2 administration in ARPE19 cells and 661W cells[2].In chicken hepatocytes, Lithium citrate tetrahydrate decreases the accumulation of lipid droplets and accelerated energy metabolism. Lithium citrate tetrahydrate protects the cells from ER stress by increasing the antioxidant status and mitochondrial functions[2]. |
Name | Lithium citrate tetrahydrate |
CAS | 6080-58-6 |
Formula | C6H13Li3O11 |
Molar Mass | 281.98 |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |