| Bioactivity | Lithium chloride hydrate, an orally active mood stabilizer, is a potent virus inhibitor and effective immunomodulatory agent. Lithium chloride hydrate has antidepressant activity by inhibiting GSK3β and promoting neurogenesis. Lithium chloride hydrate alleviates cognition dysfunction and the symptoms of acute mania and depression. Lithium chloride hydrate can also be used for research of virus infection and Alzheimer's disease[1][2][3]. |
| Invitro | Lithium chloride hydrate (5 和 20 mM，36 小时) 抑制 IBV Beaudette 感染的 BHK 细胞中的细胞病变和 IBV 复制[1]。Lithium chloride hydrate (5 和 20 mM，36 小时) 抑制 IBV 诱导的 BHK 细胞凋亡和炎症[1]。Lithium chloride hydrate (1 mg/mL) 提高诱导多能干细胞衍生神经球的效率[4]。Lithium chloride hydrate (1.2 mM，72 小时) 保护 PC12 细胞免受 Morphine (HY-P1701) 诱导的细胞凋亡[5]。 RT-PCR[1] Cell Line: |
| In Vivo | Lithium chloride hydrate (60 mg/kg，i.p.，每天两次) 改善 Sevoflurane (SEV) 诱导的大鼠记忆障碍[2]。Lithium chloride hydrate (150 mg/kg，口服，每隔一天) 刺激大鼠拔牙窝修复中的骨形成[6]。 Animal Model: |
| Name | Lithium chloride hydrate |
| CAS | 85144-11-2 |
| Formula | LiCl · xH2O |
| Molar Mass | 42.39 (anhydrous basis) |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Reference | [1]. Liu X, et al. Lithium chloride inhibits infectious bronchitis virus-induced apoptosis and inflammation. Microb Pathog. 2022 Jan;162:105352. [2]. Wang, et al. Lithium chloride ameliorates cognition dysfunction induced by sevoflurane anesthesia in rats. FEBS Open Bio. 2020 Feb;10(2):251-258. [3]. Wang Z, et alL. Baicalin Coadministration with Lithium Chloride Enhanced Neurogenesis via GSK3β Pathway in Corticosterone Induced PC-12 Cells. Biol Pharm Bull. 2022 May 1;45(5):605-613. [4]. Tafreshi AP, Set al. Lithium chloride improves the efficiency of induced pluripotent stem cell-derived neurospheres. Biol Chem. 2015 Aug;396(8):923-8. [5]. Sahebgharani M, et al. Lithium chloride protects PC12 pheochromocytoma cell line from morphine-induced apoptosis. Arch Iran Med. 2008 Nov;11(6):639-48. |
Lithium chloride hydrate
CAS: 85144-11-2 F: LiCl · xH2O W: 42.39 (anhydrous basis)
Lithium chloride hydrate, an orally active mood stabilizer, is a potent virus inhibitor and effective immunomodulatory a
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