| Bioactivity | Lipid peroxidation inhibitor 1 is a lipid peroxidation inhibitor with an IC50 of 0.07 μM. |
| Target | IC50: 0.07μM (lipid peroxidation) |
| Invitro | Among the compounds synthesized, Lipid peroxidation inhibitor 1 (26n) exhibits potent effects in the inhibition of lipid peroxidation, with an IC50 of 0.07 μM[1]. |
| In Vivo | Basic molecules 8a and 27 exhibit significant effects against (methamphetamine) MAP-induced hypermotility. Except in these compounds, a phenyl group adjacent to the methyl group in position 2 at a distance seems to be indispensable (compare compounds 26m, o, p with compounds Lipid peroxidation inhibitor 1 (26n), q, r). Among these compounds, Lipid peroxidation inhibitor 1 which has a phenylpiperidinyl group in position 2 is found to be most effective[1]. |
| Name | Lipid peroxidation inhibitor 1 |
| CAS | 142873-41-4 |
| Formula | C24H32N2O |
| Molar Mass | 364.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ohkawa S, et al. 5-aminocoumarans: dual inhibitors of lipid peroxidation and dopamine release with protectiveeffects against central nervous system trauma and ischemia. J Med Chem. 1997 Feb 14;40(4):559-73. |