| Bioactivity | Liperfluo, a marker of ferroptosis, is a useful fluorescent probe for investigating the roles of lipid peroxidation in a variety of cell pathophysiologies. Liperfluo reduces lipid hydroperoxides to lipid alcohols and is used for imaging lipid hydroperoxides in living cells[1][2][3]. |
| Invitro | Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs).1. 玻璃底培养皿中的细胞在 RPMI 1640 中用 50 µM H2O2 在 37 °C 下处理 2 小时。去除 H2O2 后，细胞用汉克氏平衡盐溶液 (HBSS) 洗涤 3 次。2. 在 37°C 下用 10 µM Liperfluo 在 HBSS 中处理细胞 30 分钟。去除 Liperfluo 后，细胞用 HBSS 洗涤 3 次。3. 使用 BZ-8000 荧光显微镜从 3 个独立的培养皿中获取荧光图像[1]。 |
| Name | Liperfluo |
| CAS | 1448846-35-2 |
| Formula | C51H41N2O8P |
| Molar Mass | 840.85 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
| Reference | [1]. Kazuo Tomita, et al. MiR-7-5p Is Involved in Ferroptosis Signaling and Radioresistance Thru the Generation of ROS in Radioresistant HeLa and SAS Cell Lines. Int J Mol Sci. 2021 Aug 2;22(15):8300. [2]. Elizabeth M Kenny, et al. Ferroptosis Contributes to Neuronal Death and Functional Outcome After Traumatic Brain Injury. Crit Care Med. 2019 Mar;47(3):410-418. [3]. Kazunori Yamanaka, et al. A novel fluorescent probe with high sensitivity and selective detection of lipid hydroperoxides in cells. RSC Advances, 2012, 2, 7894–7900. |
Liperfluo
CAS: 1448846-35-2 F: C51H41N2O8P W: 840.85
Liperfluo, a marker of ferroptosis, is a useful fluorescent probe for investigating the roles of lipid peroxidation in a
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