| Bioactivity | Linalool-d6 is deuterated labeled Trans-Anethole (HY-N0367). Trans-Anethole ((E)-Anethole), a phenylpropene derivative isolated from Foeniculum vulgare, shows estrogenic activity at lower concentrations and cytotoxic at higher concentrations in cancer cell lines[1][2]. Trans-Anethole ((E)-Anethole) contributes a large component of the odor and flavor of anise and fennel, anise myrtle, liquorice, camphor, magnolia blossoms, and star anise[3]. |
| Invitro | 氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。Linalool (0-2000 μM, 24-72 h) 可以通过氧化应激诱导癌细胞 (U87-MG，HepG-2，SW620 and so on) 凋亡，同时保护正常细胞 PC12[4]。Linalool (0-2000 mg/mL, 0-72 h) 通过破坏细胞膜发挥抗菌作用[4]。Linalool (0-2 mM, 24-48 h) 通过诱导 G0/G1 和/或 G2/M 细胞周期停滞来抑制 A549 细胞增殖，而不影响正常肺 WI-38 细胞的细胞活力。Linalool 抑制 A549 细胞迁移[5]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Linalool-d6 相关抗体: |
| In Vivo | Linalool (每隔 1 天口服 150，200，250 mg/kg，持续 21 天) 使 S-180 实体瘤小鼠模型的肿瘤生长降低 50%，在正常肝脏中抑制氧化，在肿瘤组织中促进氧化[6]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| Formula | C10H12D6O |
| Molar Mass | 160.29 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. |