| Bioactivity | Leupeptin hemisulfate is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin hemisulfate potently inhibits serine, cysteine and threonine proteases. Leupeptin hemisulfate inhibits Mpro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity[1][2][3]. |
| Invitro | Leupeptin hemisulfate (0.06-200 µM; 72 h) 显著抑制 Vero 细胞中 SARS-CoV-2 病毒 RNA (vRNA) 的拷贝数[1]。Leupeptin hemisulfate 抑制 Vero 细胞中 SARS-CoV-2 的 RNA 水平，EC50 值为 42.34 µM[1]。Leupeptin hemisulfate 对 Mpro 有一定的抑制活性，其 IC50 值为127.2 µM[1]。Leupeptin hemisulfate 对人类冠状病毒 229E 株的 IC50 值为 0.4 µg/mL (约 1 µM)[1]。 RT-PCR[1] Cell Line: |
| Name | Leupeptin hemisulfate |
| CAS | 103476-89-7 |
| Shortening | Ac-LLR-CHO |
| Formula | C20H38N6O4.1/2H2SO4 |
| Molar Mass | 475.59 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
Leupeptin hemisulfate
CAS: 103476-89-7 F: C20H38N6O4.1/2H2SO4 W: 475.59
Leupeptin hemisulfate is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin hemisulfate potently inhibit
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