| Bioactivity | Leukotriene A4 (LTA4) is synthesized in mast cells, eosinophils, and neutrophils from arachidonic acid by 5-lipoxygenase (5-LO), which exhibits both lipoxygenase and LTA4 synthase activities. LTA4 is rapidly metabolized by LTA4 hydrolase or LTC4 synthase to LTB4 or LTC4, respectively.2 LTA4, from leukocytes, is known to undergo transcellular metabolism in platelets, erythrocytes, and endothelial cells.3 Further metabolism of LTA4 by 15-LO leads to lipoxin biosynthesis.2 LTA4 as a free acid is highly unstable. The methyl ester is stable and can be readily hydrolyzed to the free acid as needed. |
| CAS | 73466-12-3 |
| Formula | C21H32O3 |
| Molar Mass | 332.48 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Samuelsson, et al. Leukotrienes and lipoxins: Structures, biosynthesis, and biological effects. Science 237(4819), 1171-1176 (1987). |
Leukotriene A4 methyl ester
CAS: 73466-12-3 F: C21H32O3 W: 332.48
Leukotriene A4 (LTA4) is synthesized in mast cells, eosinophils, and neutrophils from arachidonic acid by 5-lipoxygenase
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.