| Bioactivity | LeuRS-IN-2 (Compound 9) is a Wolbachia leucyl-tRNA synthetase (LeuRS) inhibitor in the presence of adenosine monophosphate (AMP) with an EC50 value of 6 nM, efficiently arresting the growth of pathogenic host. LeuRS-IN-2 forms adenosine-based adducts inhibiting protein synthesis, which is promising for research of new antimicrobials with disrupting microbiota[1]. |
| Invitro | LeuRS-IN-2 (9 μM, 7 天) 在 Wolbachia 感染模型的纤维素功效中具有良好的转化功能，EC50 值为 90 nM[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> LeuRS-IN-2 相关抗体: |
| Formula | C19H24BBrN2O3 |
| Molar Mass | 419.12 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hoffmann G, et al. Targeting a microbiota Wolbachian aminoacyl-tRNA synthetase to block its pathogenic host[J]. Sci Adv. 2024 Jul 12;10(28):eado1453. |