| Bioactivity | Letrozole (CGS 20267) is a potent, selective, reversible and orally active non-steroidal inhibitor of aromatase, with an IC50 of 11.5 nM. Letrozole selective inhibits estrogen biosynthesis, and can be used for the research of breast cancer[1][2][3]. | ||||||||||||
| Invitro | Letrozole (0.1-100 nM; 24-96 h) significantly inhibits growth of the MCF-7 epithelial breast cancer cells in a dose- and time-dependent manner[2].Letrozole (10 nM) significantly suppresses the stimulatory effects of testosterone on MCF-7 cell proliferation[2].Letrozole (10 nM; 24-48 h) suppresses the levels of secreted metalloproteinases (MMP‐2 and MMP‐9) in MCF-7 cells[2]. Cell Viability Assay[2] Cell Line: | ||||||||||||
| Name | Letrozole | ||||||||||||
| CAS | 112809-51-5 | ||||||||||||
| Formula | C17H11N5 | ||||||||||||
| Molar Mass | 285.30 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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