| Bioactivity | Leteprinim potassium (AIT-082) is a hypoxanthine derivative neurotrophic agent. Leteprinim potassium can induce brain-derived neurotrophic factor (BDNF) mRNA production following spinal cord lesions, and nerve growth factor (NGF) mRNA production in basal forebrain. Leteprinim potassium reduces glutamate toxicity in cultured hippocampal neurons. Leteprinim potassium increases heme-oxygenase 1 and 2 mRNA levels that play role in cellular defense against reactive oxygen species. Leteprinim potassium has neuroprotective activity[1]. |
| In Vivo | Leteprinim potassium (60 mg/kg; IP; single dosage) significantly reduced the number of apoptotic neurons in hypoxic-ischemic brain injury rat pups[1]. Animal Model: |
| Name | Leteprinim potassium |
| CAS | 192564-13-9 |
| Formula | C15H12KN5O4 |
| Molar Mass | 365.39 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Gencpınar P, et al. Effects of neotrofin on neonatal hypoxic ischemic brain injury. Neurosci Lett. 2011 Nov 14;505(2):205-10. |
Leteprinim potassium
CAS: 192564-13-9 F: C15H12KN5O4 W: 365.39
Leteprinim potassium (AIT-082) is a hypoxanthine derivative neurotrophic agent. Leteprinim potassium can induce brain-de
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