| Bioactivity | Leptomycin A, a Streptomyces metabolite, is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins. Leptomycin A suppresses HIV-1 replication. Less potent than Leptomycin B[1][2]. | ||||||||||||
| Name | Leptomycin A | ||||||||||||
| CAS | 87081-36-5 | ||||||||||||
| Formula | C32H46O6 | ||||||||||||
| Molar Mass | 526.70 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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