Leminoprazole

CAS: 104340-86-5 F: C19H23N3OS W: 341.47

Leminoprazole (NC 1300O3) is an inhibitor for acid pump, H+ K+-ATPase,. Leminoprazole stimulates the secretion and synth

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Bioactivity	Leminoprazole (NC 1300O3) is an inhibitor for acid pump, H+ K+-ATPase,. Leminoprazole stimulates the secretion and synthesis of gastric mucus, attenuates gastric ulcers. Leminoprazole is orally active[1][2][3].
Invitro	Leminoprazole 通过形成共价二硫键不可逆地抑制兔胃囊泡中的 H+,K+-ATPase，IC50 为 5.3 和 19 μM[1]。Leminoprazole 抑制组胺、卡巴胆碱、胃泌素和 db-cAMP 刺激的酸分泌，IC50 分别为 0.4，0.35，0.25 和 0.56 μM[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Leminoprazole 相关抗体:
In Vivo	Leminoprazole (10-90 mg/kg，口服，单剂量) 在 Donryu 大鼠模型中促进胃粘液合成，抑制胃酸分泌[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	104340-86-5
Formula	C19H23N3OS
Molar Mass	341.47
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Masuda M, et al., [Studies on the inhibitory action of leminoprazole against rabbit gastric H+,K(+)-ATPase]. Nihon Yakurigaku Zasshi. 1994 Oct;104(4):325-35. Japanese. [2]. Saito E, et al., Inhibitory effect of leminoprazole on acid secretion in parietal cells isolated from guinea pig gastric mucosa. Jpn J Pharmacol. 1995 May;68(1):19-23. [3]. Takahashi S, et al., Mechanism by which orally administered leminoprazole stimulates mucus synthesis in rats. Pharmacology. 1998 Jul;57(1):47-56.

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