| Bioactivity | Lecanemab (BAN-2401) is an IgG1 anti-soluble aggregated amyloid beta (Aβ) monoclonal antibody. Lecanemab shows activity across oligomers, protofibrils and insoluble fibrils. Lecanemab can be used for the research of Alzheimer's Disease[1]. |
| Invitro | Lecanemab (0.01-10000 ng/mL) 与大小原纤维结合的 IC50 值均为 0.8 nM[1]。 Lecanemab 对 Aβ 单体的 Kd 值为 2.3 μM[1]。 Lecanemab 分别与大小原纤维结合的 KD1 值分别为 0.97 和 0.16 nM[1]。 |
| Name | Lecanemab |
| CAS | 1260393-98-3 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Söderberg L, et al. Lecanemab, Aducanumab, and Gantenerumab - Binding Profiles to Different Forms of Amyloid-Beta Might Explain Efficacy and Side Effects in Clinical Trials for Alzheimer's Disease. Neurotherapeutics. 2022 Oct 17. |