Bioactivity | Lauryl maltose neopentyl glycol (LMNG) is a detergent that can solubilize and stabilize membrane proteins. Lauryl maltose neopentyl glycol extracts integral membrane proteins from membranes, and improves substantially the stability of various membrane proteins, including G protein-coupled receptors and respiratory complexes[1][2]. |
Invitro | Lauryl maltose neopentyl glycol can yield essentially soluble membrane proteins at detergent concentrations that do not inhibit the cell-free reaction[2]. |
Name | Lauryl maltose neopentyl glycol |
CAS | 1257852-96-2 |
Formula | C47H88O22 |
Molar Mass | 1005.19 |
Appearance | Solid |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | -20°C, stored under nitrogen, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture) |
Reference | [1]. Breyton C, et, al. Assemblies of lauryl maltose neopentyl glycol (LMNG) and LMNG-solubilized membrane proteins. Biochim Biophys Acta Biomembr. 2019 May 1;1861(5):939-957. [2]. Fogeron ML, et, al. Wheat germ cell-free expression: Two detergents with a low critical micelle concentration allow for production of soluble HCV membrane proteins. Protein Expr Purif. 2015 Jan;105:39-46. |