| Bioactivity | LasR-IN-3 is a LasR inhibitor against Pseudomonas aeruginosa. LasR-IN-3 induces LasR structure instability and completely dissociates LasR functioning dimeric form[1]. |
| Invitro | LasR-IN-3 (compound 7f) (4.68-150 μg/mL; 24 h) shows anti-activity against Pseudomonas aeruginosa with MIC and sub-MIC values of 56.25 μg/mL and 14.00 μg/mL[1]. LasR-IN-3 (14.00 μg/mL; 24 h, or 48 h) inhibits biofilm formation, pyocyanin, and rhamnolipids production with inhibition rate of 71.70%, 68.70%, 54.00%, respectively[1]. LasR-IN-3 (56.25 μg/mL, and 338.0 μg/mL; 24 h) is safe to normal cell line (HDFa)[1]. LasR-IN-3 (14.00 μg/mL; 24 h) decreases lasR and rhlR gene expression and inhibits the QS-dependent biofilm formation and virulence factors[1]. RT-PCR[1] Cell Line: |
| Name | LasR-IN-3 |
| Formula | C22H19N3O2 |
| Molar Mass | 357.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |