| Bioactivity | Larsucosterol (DUR-928) sodium, a cholesterol metabolite, is a potent liver X receptor (LXR) antagonist. Larsucosterol sodium as a potent endogenous regulator decreases lipogenesis. Larsucosterol sodium inhibits the cholesterol biosynthesis via decreasing mRNA levels and inhibiting the activation of SREBP-1[1][2][3]. |
| Invitro | Larsucosterol (DUR-928; 0-25 μM; 8 h; HepG2 cells) sodium inhibits cholesterol biosynthesis by decreasing HMG-CoA reductase mRNA levels and decreases free [14C] cholesterol in a dose-dependent manner[1].Larsucosterol (0-25 μM; 6 h; HepG2 cells) sodium inhibits HMG-CoA reductase expression by inhibition of both SREBP1 activation and expression in hepatocytes[1].Larsucosterol (0-50 μM; 48 h) sodium increases cell proliferation and decreases apoptosis in macrophages[2].Larsucosterol (0-25 μM; 48 h; macrophages) sodium inhibits activation of liver oxysterol receptor LXRα[2]. Cell Proliferation Assay[2] Cell Line: |
| Name | Larsucosterol sodium |
| CAS | 1174047-40-5 |
| Formula | C27H45NaO5S |
| Molar Mass | 504.70 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Larsucosterol sodium
CAS: 1174047-40-5 F: C27H45NaO5S W: 504.70
Larsucosterol (DUR-928) sodium, a cholesterol metabolite, is a potent liver X receptor (LXR) antagonist. Larsucosterol s
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