Laprafylline_product_DataBase

Bioactivity	Laprafylline (S 9795), a xanthine derivative, is a bronchodilator. Laprafylline has potent anti-bronchoconstrictive effects, inhibiting action on mast cell degranulation and phosphodiesterase (PDE) activity (IC50 of 6 μM)[1].
In Vivo	在雄性 Sprague Dawley 大鼠中，无论给药剂量如何，Laprafylline（S 9795；2.5-10mg/kg；iv）从血浆中迅速消失， t1/2 为 0.8 小时。 Laprafylline 分布容积较高（约 3 L/kg），但总清除率也较高（约 40 mL/min/kg）。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	90749-32-9
Formula	C29H36N6O2
Molar Mass	500.64
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. G Bianchi, et al. Kinetics and brain uptake of S 9795, a new xanthine derivate, in rats. Eur J Drug Metab Pharmacokinet. 1989 Jul-Sep;14(3):201-8.

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