| Bioactivity | Lapaquistat (T-91485), a cholesterol biosynthesis inhibitor, is the active metabolite of Lapaquistat acetate (HY-16274). Lapaquistat can decrease statin-induced myotoxicity in lipid-lowering therapy[1]. | ||||||||||||
| Invitro | Lapaquistat inhibits cholesterol biosynthesis in differentiated RD (rhabdomyosarcoma) cells, with an IC50 of 36 nM[1].Lapaquistat potently inhibits cholesterol synthesis in RD cells, with an IC25 exceeded 100 μM[1].Lapaquistat concentration-dependently inhibits cholesterol biosynthesis in human skeletal myocytes, with an IC50 of 45 nM[1]. | ||||||||||||
| Name | Lapaquistat | ||||||||||||
| CAS | 189059-71-0 | ||||||||||||
| Formula | C31H39ClN2O8 | ||||||||||||
| Molar Mass | 603.10 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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Lapaquistat
CAS: 189059-71-0 F: C31H39ClN2O8 W: 603.10
Lapaquistat (T-91485), a cholesterol biosynthesis inhibitor, is the active metabolite of Lapaquistat acetate (HY-16274).
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