Laninamivir octanoate hydrate_product_DataBase

Bioactivity	Laninamivir octanoate hydrate (CS-8958 hydrate), a prodrug of Laninamivir, is a long-acting neuraminidase (NA) inhibitor with anti-influenza virus activity. Laninamivir octanoate hydrate shows anti-influenza activity against Oseltamivir-resistant viruses, and also against the pandemic influenza viruses[1][2].
Invitro	Laninamivir octanoate (CS-8958) 对 H1N1 病毒株、H3N2 病毒株和 H2N2 (A/Singapore/1/57) 病毒株具有抑菌活性，IC50 分别为 631-1170 nM、39.2-221 nM 和 128 nM [1]。
In Vivo	Laninamivir octanoate (CS-8958；95μg/kg；鼻内的管理；3 次) 在感染前 4 h、感染后 4 h 和 17 h 处理，在小鼠感染模型中均有明显的延长寿命效果[1]。 Animal Model:
Name	Laninamivir octanoate hydrate
CAS	1233643-88-3
Formula	C21H38N4O9
Molar Mass	490.55
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Makoto Yamashita, et al. CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity. Antimicrob Agents Chemother. 2009 Jan;53(1):186-92. [2]. Hideyuki Ikematsu, et al. Laninamivir octanoate: a new long-acting neuraminidase inhibitor for the treatment of influenza. Expert Rev Anti Infect Ther. 2011 Oct;9(10):851-7.

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