Lagociclovir_product_DataBase

Bioactivity	Lagociclovir (FLG) is a nucleoside analogue that inhibits wild-type hepatitis B virus (HBV) replication in a human hepatoma cell line permanently expressing HBV[1].
Target	HBV
Invitro	Lagociclovir (FLG) (6 days) 在瞬时转染的 Huh7 细胞中表现出对 3TC-R HBV、wt HBV、PMEA-R HBV 和 3TC+PMEA-R HBV 的抑制活性，IC50 分别为 8 ± 3.8、9 ± 2.5、13 ± 3.4 和 15 ± 6.8 μM[1]。Lagociclovir (0-100 μM; 6 days) 在瞬时转染的 Huh7 细胞中抑制 HBV 野生型和耐药突变体的复制[1]。
Name	Lagociclovir
CAS	92562-88-4
Formula	C10H12FN5O3
Molar Mass	269.23
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Jacquard AC, et al. In vitro characterization of the anti-hepatitis B virus activity and cross-resistance profile of 2',3'-dideoxy-3'-fluoroguanosine. Antimicrob Agents Chemother. 2006 Mar;50(3):955-61.

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