| Bioactivity | Lactucin is an anti-inflammatory agent. Lactucin induces cancer cell apoptosis. Lactucin also shows analgesic, anticancer and antimalarial activities[1][2][3][4]. |
| Invitro | Lactucin shows moderate inhibitory activity against LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages[1].Lactucin (0-100 µM; 24 and 48 h) induces cytotoxic effects in HL-60 cells in a dose– and time-dependent manner[3].Lactucin (0-100 µM; 48 h) induces apoptosis and sub-G1 cell cycle arrest in HL-60 cells[3].Lactucin (10 μg/mL; 48 h) completely prevents Plasmodium falciparum parasitemia[4]. 0 --> Lactucin 相关抗体: Cell Viability Assay[3] Cell Line: |
| In Vivo | Lactucin (15 and 30 mg/kg; i.p.; once) decreases the spontaneous locomotor activity and shows analgesic properties in mice[2]. Animal Model: |
| Name | Lactucin |
| CAS | 1891-29-8 |
| Formula | C15H16O5 |
| Molar Mass | 276.28 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Dang T, et al. Sesquiterpenoids with diverse carbon skeletons from the roots of Cichorium glandulosum and their anti-inflammatory activities. Fitoterapia. 2019 Jul;136:104170. [2]. Gromek D, et al. Biologically active preparations from Lactuca virosa L. Phytotherapy Research, 1992, 6(5): 285-287. [3]. Zhang F H, et al. Lactucin induces potent anti-cancer effects in HL-60 human leukemia cancer cells by inducing apoptosis and sub-G1 cell cycle arrest. Bangladesh Journal of Pharmacology, 2016, 11(2): 478-484. [4]. Bischoff TA, et al. Antimalarial activity of lactucin and lactucopicrin: sesquiterpene lactones isolated from Cichorium intybus L. J Ethnopharmacol. 2004 Dec;95(2-3):455-7. |