| Bioactivity | Lactoferrin is a substance released by neutrophils. Lactoferrin is an orally active multifunctional iron binding glycoprotein. Lactoferrin prevents cell adhesion, growth and spreading of cell colonies. Lactoferrin also has antiviral activity and inhibits microbial and viral adhesion and entry into host cells. Besides, Lactoferrin has anti-inflammatory, immunomodulatory, and anti-cancer activities[1][2][3]. | ||||||
| Invitro | Lactoferrin (0-1 000 μg/mL，7 天) 以剂量依赖性方式抑制上皮细胞 (HaCaT) 生长[1]。Lactoferrin (500 μg/mL，12 天) 抑制 HaCaT 细胞集落的扩散和生长[1]。Lactoferrin (人或牛乳铁蛋白，1.41 μM 和 0.12 μM）可抑制 Vero 细胞中的 HSV-1 感染达 50%[4]。 | ||||||
| In Vivo | Lactoferrin (重组人乳铁蛋白) (1,000 mg/kg，口服灌胃，每天两次，持续 8 天) 可抑制 80% 的 T 细胞免疫功能低下的 nu/nu 小鼠鳞状细胞癌 (O12) 肿瘤的生长[5] 。Lactoferrin (牛乳铁蛋白) (100 和 200 mg/kg，口服灌胃，连续 30 天) 对败血症诱发的急性肺损伤大鼠模型显示出保护作用[6]。 Animal Model: | ||||||
| Name | Lactoferrin | ||||||
| CAS | 936541-36-5 | ||||||
| Appearance | Solid | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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| Reference | [1]. Pöllänen MT, et al. Lactoferrin impedes epithelial cell adhesion in vitro. J Periodontal Res. 1998 Jan;33(1):8-16. [2]. Berlutti F, et al. Antiviral properties of lactoferrin--a natural immunity molecule. Molecules. 2011 Aug 16;16(8):6992-7018. [3]. Cutone A, et al. Lactoferrin's Anti-Cancer Properties: Safety, Selectivity, and Wide Range of Action. Biomolecules. 2020 Mar 15;10(3):456. [4]. Marchetti M, et al. Lactoferrin inhibits herpes simplex virus type 1 adsorption to Vero cells. Antiviral Res. 1996 Mar;29(2-3):221-31. [5]. Varadhachary A, et al. Oral lactoferrin inhibits growth of established tumors and potentiates conventional chemotherapy. Int J Cancer. 2004 Sep 1;111(3):398-403. [6]. Han N, et al. Effect of bovine lactoferrin as a novel therapeutic agent in a rat model of sepsis-induced acute lung injury. AMB Express. 2019 Oct 31;9(1):177. |