Lacto-N-fucopentaose III_product_DataBase

Bioactivity	Lacto-N-fucopentaose III (LNFP-III) is an immune modulator. Lacto-N-fucopentaose III reduces the severity of experimental autoimmune encephalomyelitis (EAE) and CNS inflammation[1].
Invitro	Lacto-N-fucopentaose III glycan (LNFP-III; 50 μg/mL; 48 h) 诱导炎症单核细胞产生一氧化氮。Lacto-N-fucopentaose III 减少树突状细胞跨脑内皮的迁移[1]。 Lacto-N-fucopentaose III glycan (50 μg/mL; 48 h) 显著增加精氨酸酶 I (Aldh1a2)、醛脱氢酶 1、A2 亚家族 (Aldh1a2)、吲哚胺 2,3-双加氧酶 1 (Ido1) 和血红素加氧酶 1 (Homx1) mRNA的表达[1]。
In Vivo	Lacto-N-fucopentaose III glycan (50 μg/mouse; i.v.; twice a week for 2 weeks) 显著降低实验性自身免疫性脑脊髓炎 (EAE) 和中枢神经系统炎症的严重程度，并扭曲小鼠对 Th2 显性谱的外周免疫反应[1]。Lacto-N-fucopentaose III (35 μg dextran conjugate/mouse; s.c.; daily for 2 weeks) 改善 Gulf War Illness 小鼠模型的急性和持续性海马突触可塑性和传递缺陷[2]。
Name	Lacto-N-fucopentaose III
CAS	25541-09-7
Formula	C32H55NO25
Molar Mass	853.77
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Zhu B, et al. Immune modulation by Lacto-N-fucopentaose III in experimental autoimmune encephalomyelitis. Clin Immunol. 2012 Mar;142(3):351-61. [2]. Brown KA, et al. Lacto-N-fucopentaose-III ameliorates acute and persisting hippocampal synaptic plasticity and transmission deficits in a Gulf War Illness mouse model. Life Sci. 2021 Aug 15;279:119707.

PeptideDB

Lacto-N-fucopentaose III

CAS: 25541-09-7 F: C32H55NO25 W: 853.77